Description
γ-glutamyl transferase is an enzyme that transfers gamma-glutamyl functional groups. It is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker. GGT catalyzes the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione and drug and xenobiotic detoxification. Other lines of evidence indicate that GGT can also exert a prooxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology.
Abbr
γ-GT, Native (Bovine)
Enzyme Commission Number
EC 2.3.2.2
Contaminants
ALP: 0.2% (Dimension Clinical Chemistry System)CPK: 1%LDH: 1%SGOT/AST: 1%SGPT/ALT: 0.01%Ammonia: 0.1 micromole/mg
Specificity
> 30 U/mg protein
Unit Definition
One unit will catalyze the transfer of one micromole of the glutamyl moiety from gamma-glutamyl-3-carboxy-4-nitranilide to glycylglycine per minute at 37°C.
Synonyms
EC 2.3.2.2; glutamyl transpeptidase; α-glutamyl transpeptidase; γ-glutamyl peptidyltransferase; γ-glutamyl transpeptidase (ambiguous); γ-GPT; γ-GT; γ-GTP; L-γ-glutamyl transpeptidase; L-γ-glutamyltransferase; L-glutamyltransferase; GGT (ambiguous); γ-glutamyltranspeptidase (ambiguous); γ-glutamyltransferase; 9046-27-9; GGTP
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