Description
The medicine Defibrase is the trade name given to batroxobin and is isolated from the venom of Bothrops moojeni. It functions as an defibrinogenating agent and is used for patients with thrombosis. The batroxobin from the snake Bothrops atrox is patented as Reptilase and used as a hemostatic drug.
Abbr
Defibrase (Bothrops atrox snake)
Source
Bothrops atrox snake
Appearance
White lyophilized powder
Activity
pecific activity(CP): > 1,200 units / mg protein
Purity
Purity (SDS-PAGE): No band other than 31000-41000 Purity (HPLC): > 90.0%
Unit Definition
TAME Unit: One Unit hydrolyzes 1µmole of p-toluene-sulfonyl-L-arginine methyl ester (TAME) per minute at 25°C, pH 8.2, in the presence of 10mM calcium. For TRSEQZ: One Unit is equivalent to one micromole of TCA soluble products, measured as tyrosine, released from 2% casein per minute, in 0.05M Tris-HCl, pH 7.6, at 37°C, in a 30 minute reaction.
Storage
Store in an airtight container, protect from light, at a temperature of < 10°C.
Synonyms
Defibrase; batroxobin; reptilase
Download Datasheet