Description
Restrictocin from Aspergillus restrictus is a ribosome-inactivating protein that acts by specifically cleaving rRNA. Approximately 70% of the protein is active restrictocin. Restrictocin shares a high degree of amino acid sequence homology with mitogillin, a ribotoxin that cleaves a single phosphodiester bond of the 29S rRNA of eukaryotic ribosomes. Restrictocin is thought to be activated during the process of secretion.
Abbr
Restrictocin, Native (Aspergillus restrictus)
Source
Aspergillus restrictus
Applications
Restrictocin from Aspergillus restrictus is used to inhibit protein synthesis. It may be useful as a component of immunotoxins. This product is provided as a lyophilized powder.
Synonyms
Restrictocin; 1406-72-0
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