Description
MK-1775 can inhibit Wee1 kinase with IC50 of 5.2 nM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C27H32N8O2
Chemical Name
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one
Solubility
DMSO 80 mg/mL Water
In vitro
MK-1775, a small molecule Wee1 inhibitor, can inhibit Wee1 which is involved in G(2) checkpoint signaling. MK-1775 inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cells. MK-1775 abrogates G(2) DNA damage checkpoint, leading to apoptosis.
In vivo
MK-1775 can abrogate the radiation-induced G(2) checkpoint and enhanced radiosensitivity in established glioblastoma cell lines in vitro and in vivo.
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