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Mitoxantrone HCl
Cat No.
CEI-0277
Description
Mitoxantrone HCl is a DNA-reactive agent and can inhibit topoisomerase II.
Alias
Novantrone
CAS No.
70476-82-3
Molecular Weight
517.4
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
Novantrone
Targets
Topoisomerase II
Molecular Formula
C22H30Cl2N4O6
Chemical Name
1,4-dihydroxy-5,8-bis(2-(2-hydroxyethylamino)ethylamino)anthracene-9,10-dione dihydrochloride
Solubility
DSMO 89 mg/mL Water 89 mg/mL Ethanol
In vitro
Mitoxantrone HCl is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone HCl also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II.
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