Description
Mitogen-activated protein kinases (MAPK) are protein kinases that are specific to the amino acids serine, threonine, and tyrosine. MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.
Abbr
MAPK, Recombinant (Rat)
Product Overview
> 95% (SDS-PAGE), buffered aqueous glycerol solution, recombinant, expressed in E. coli (N-terminal histidine tagged)
Form
buffered aqueous glycerol solution
Molecular Weight
mol wt 42 kDa
Unit Definition
One unit of activated MAP kinase will transfer 1 nmole of phosphate from ATP to myelin basic protein per min at 30°C.
Buffer
Solution in 20 mM Tris, pH 7.5, 150 mM NaCl, 1 mM EGTA, 10% glycerol, 1 mM DTT, and 0.03% Brij.
Pathway
ARMS-mediated activation, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem
Function
ATP binding; ATP binding; MAP kinase activity; MAP kinase activity; MAP kinase activity; MAP kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; kinase activity; kinase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; phosphatase binding; phosphatase binding; phosphotyrosine binding; phosphotyrosine binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; transcription factor binding
Synonyms
ERK2; Extracellular-signal regulated kinase; MAP Kinase Activated from rat; MAPK; Mitogen activated protein kinase
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