Description
MG-132 (ZLLLal) can potently inhibit proteasome with IC50 of 100 nM.
Storage
2 years at -20 centigrade
Molecular Formula
C26H41N3O5
Chemical Name
benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate
Solubility
DSMO Water Ethanol
In vitro
MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 uM. MG-132 also inhibits calpain with IC50 of 1.2 uM. MG-132 (10 uM) potently inhibits TNF-alpha-induced NF-kappaB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IkappaBalpha degradation.
In vivo
Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, beta-dystroglycan, alpha-bdystroglycan, and alpha-sarcoglycan in skeletal muscle fibers.
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