Description
Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimers disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
β-secretase; β-site Alzheimers amyloid precursor protein cleaving enzyme 1 (BACE1)
Reaction
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu┼Asp-Ala-Glu-Phe in the Swedish variant of Alzheimers amyloid precursor protein
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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