Description
Matriptase-2 (TMPRSS6) is a type II transmembrane serine protease mainly produced by the liver. It acts as a potent negative regulator of hepcidin, a hepatic peptide hormone and integral player in regulating iron homeostasis.
Abbr
Matriptase-2, Recombinant (Human)
Source
Drosophila Schneider 2 (S2) cells
Form
Liquid. In 100mM TRIS-HCl, pH 9.0, containing 150 mM sodium chloride and 20% glycerol.
Enzyme Commission Number
EC 3.4.21.-
Molecular Weight
~84 kDa; a-subunit: ~56kDa; b-subunit: ~28kDa
Purity
Purified by multi-step chromatography.
Unit Definition
One unit is defined as the amount of enzyme that releases 10pmol of AMC per min. at 37°C in the presence of 50µM Boc-Gln-Ala-Arg-AMC.
Stability
Stable for at least 6 months when stored at -20°C. Recommended Assay Buffer: 100mM TRIS, pH 9.0, containing 0.5mg/ml BSA. Do not store diluted solutions.
Storage
Short Term Storage: -20°C; Long Term Storage: -80°C
Synonyms
Transmembrane protease serine 6; TMPRSS6; Matriptase-2
Download Datasheet