Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
LY335979 (Zosuquidar 3HCl)
Cat No.
CEI-0254
Description
LY335979 can potently inhibit P-gp with Ki of 59 nM.
Alias
RS-33295-198
CAS No.
167465-36-3
Molecular Weight
636.99
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
RS-33295-198
Targets
P-gp
Molecular Formula
C32H31F2N3O2.3HCl
Chemical Name
1-Piperazineethanol, 4-[(1aalpha,6alpha,10balpha)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-alpha-[(5-quinolinyloxy)methyl]-,trihydrochloride
Solubility
DMSO 127 mg/mL Water 23 mg/mL Ethanol
In vitro
As a selective inhibitor of P-gp, LY335979 can potently inhibit P-gp with Ki of 59 nM, but does not modulate MRP-mediated resistance by MRP1 (ABCC1) and MRP2 (ABCC2). LY335979 is 500-1500 times more potent than cyclosporin A or verapamil in restoring Pgp substrate accumulation in the MDR cell line HL60/VCR. LY335979 could effectively block Pgp function on isolated CD56(+) lymphocytes and CD56(+) lymphocytes in whole blood with IC50 of 1.2 nM and 174 nM.
Download
Download Datasheet