Description
LY2157299 can TGF-beta receptor I with IC50 of 56 nM.
Storage
2 years at -20centigrade Powder
Targets
TGF-beta receptor I
Molecular Formula
C22H19N5O
Chemical Name
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Solubility
DMSO 74 mg/mL Water
In vitro
LY2157299 is a new type I receptor TGF-beta kinase inhibitor. LY-2157299 could inhibit TGF-beta-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells. In vivo administration of LY-2157299 ameliorated anemia in a TGF-beta overexpressing transgenic mouse model of bone marrow failure. Treatment with LY-2157199 stimulated hematopoiesis from primay MDS bone marrow specimens.
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