Description
L-Methionine γ-Lyase or methioninase has been shown to have anti-tumor effects by depleting methionine from methionine-dependent tumors making them more sensitive to traditional chemotherapies.
Abbr
L-Methionine γ-Lyase, Recombinant
Applications
L-Methionine γ-lyase has been used in a study to assess catabolism of volatile sulfur compound precursors by Brevibacterium linens and Geotrichum candidum. It has also been used in a study to investigate the enzymatic pr ocessing of fluorinated methionine analogs.
Product Overview
L-Methionine γ-lyase is a pyridoxal phosphate-containing enzyme that converts L-methionine to α-ketobutyrate, ammonia and methyl mercaptan.
Form
Supplied as a lyophilized powder containing pyridoxal-5′-phosphate and potassium phosphate
Enzyme Commission Number
EC 4.4.1.11
Activity
> 0.2 unit/mg solid
Unit Definition
One unit iwill convert 1 micromole of L-methionine to 2-ketobutyrate per minute at pH 7.0 at 37°C.
Warnings
Expressed in E. coli from a proprietary gene
Synonyms
L-methioninase; methionine lyase; methioninase; methionine dethiomethylase; L-methionine γ-lyase; L-methionine methanethiol-lyase (deaminating); EC 4.4.1.11; methionine γ-lyase
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