Description
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM.
Alias
2-Cyano-N-(2, 5-dibromophenyl)-3-hydroxy-2-butenamide
Product Overview
BTK Inhibitor
Purity
98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)
Synonyms
2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Molecular Formula
C11H8Br2N2O2
Solubility
DMSO (10 mg/ml) and ethanol (15 mg/ml)
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