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Letrozole
Cat No.
CEI-0351
Description
Letrozole
Alias
CGS 20267
CAS No.
112809-51-5
Molecular Weight
285.3
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
CGS 20267
Targets
estrogen receptors
Molecular Formula
C17H11N5
Solubility
DMSO 57 mg/mL, Water
In vitro
Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM. Letrozole potently inhibits aromatase derived from a variety of different sources including human placental microsomes, particulate fractions of human breast cancer, rat ovarian microsomes, MCF-7 cells transfected with aromatase (MCF-7Ca), JEG-3 human choriocarcinoma cells, CHO cells, hamster ovarian tissue, and particulate fractions of human breast cancer with IC50 of 11, 2, 7, 0.07, 0.07, 1.4, 20 and 0.8 nM.
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