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Lesinurad
Cat No.
CEI-1397
Product Overview
Lesinurad is an inhibitor of URAT1 that promoting renal uric acid excretion. URAT1 is a transporter in the kidney that regulates uric acid excretion from the body. In the clinical study, lesinurad potently inhibit URAT1 as well as OAT4, another transporter responsible for the renal resorption of urate. In a study, 21 people with hyperuricemia or gout (sUA >= 8.0 mg/dL) were randomized to lesinurad, open-label allopurinol or placebo. Most of the lesinurad-treated patients had sUA <6 mg/dL after seven days, which were the same effect to patients receiving allopurinol and better than placebo. Also, Lesinurad showed well tolerated in the study. Compared with probenecid, whose efficacy is reducing patients with renal insufficiency, lesinurad may be effective in patients with mildly impaired renal function.
CAS No.
878672-00-5
Molecular Weight
404.28
Purity
0.98
Storage
Store at -20°C
Synonyms
RDEA 594; RDEA-594; RDEA594
Targets
URAT1
Molecular Formula
C17H14BrN3O2S
Chemical Name
2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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