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LDN193189
Cat No.
CEI-0399
Description
Cell-permeable. LDN193189 is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN-193189 has been used to reduce ectopic ossification in a mouse model. The role of BMP2 signals in the growth and angiogenesis of non-small-cell lung carcinoma (NSCLC) also suggest LDN-193189 may be a potent inhibitor of lung tumors.
Alias
DM-3189
Appearance
White solid
Product Overview
A potent BMP type I receptor inhibitor
CAS No.
1062368-24-4(freebase)
Molecular Weight
265.3
Purity
>98%
Storage
-20 centigrade
Synonyms
DM-3189
Targets
ALK2, ALK3
Molecular Formula
C 25 H 22 N 6 .HCl
Chemical Name
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, hydrochloride
Solubility
DMSO or EtOH
Shipping Conditions
RT
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