Description
Lactosyl Ceramide neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of ERK 1 (p44 MAP kinase). Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, and c-fos expression in human aortic smooth muscle cells.
Applications
An inducer of Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, c-fos expression
Solubility
Soluble in ethanol, methanol, chloroform, and chloroform/methanol (91) (10 mg/ml).