Chemical Name
2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
In vitro
KU-60019 is an improved more water-soluble inhibitor of the ATM kinase, while displaying similar target selectivity. KU-60019 displays 3- to 10-fold more potency than KU-55933 at blocking radiation-induced phosphorylation of key ATM protein targets such as p53, gamma-H2AX, and CHK2, in human glioma U87 and U1242 cells. Consistent with the inhibition of prosurvival AKT signaling, KU-60019 at 3 uM significantly inhibits migration and invasion of human glioma U87 cells by >70% and 60%.
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