Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
KU-0063794
Cat No.
CEI-0142
Description
Ku-0063794 can inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM.
CAS No.
938440-64-3
Molecular Weight
465.54
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
mTORC1, mTORC2
Molecular Formula
C25H31N5O4
Chemical Name
(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
Solubility
DMSO 16 mg/mL Water
In vitro
Ku-0063794 can inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM without inhibiting the activity of 76 other protein kinases or seven lipid kinases. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). Ku-0063794 can induce a much greater dephosphorylation of the mTORC1 substrate 4E-BP1 (eukaryotic initiation factor 4E-binding protein 1) than rapamycin, even in mTORC2-deficient cells, suggesting a form of mTOR distinct from mTORC1, or mTORC2 phosphorylates 4E-BP1. Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest.
Download
Download Datasheet