Description
Kallikreins are serine protease enzymes having various physiological functions. Kallikreins are implicated in carcinogenesis and have potenital as novel cancer disease biomarkers. KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. Human Kallikrein-1, also called as Kallidinogenase, Kininogenase or Kininogenin, is an active protein enzyme present in saliva, pancreatic juices, and urine that catalyzes the proteolysis of bradykininogen to bradykinin. Kallikrein-1, which derived from human or porcine, have been used as drugs for a long time, they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels.
Abbr
KLK1, Recombinant (Human)
Appearance
Sterile Filtered white lyophilized powder.
Product Overview
KLK1 Human Recombinant produced in Yeast is a single, glycosylated, polypeptide chain containing 238 amino acids and having a molecular mass of 28-32 kDa. KLK1 Human Recombinant is purified by proprietary chromatographic techniques.
Molecular Weight
28-32 kDa
Purity
Greater than 98.0% as determined by both (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Stability
Lyophilized KLK1although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution KLK1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Buffer
Lyophilized from a solution containing 1xPBS.
Synonyms
KLK1; KLK-1; HK1; HK-1; KLKR; KLK6; Tissue Kallikrein; Hklk1; EC 3.4.21.35; Kidney/pancreas/salivary gland kallikrein; Kallikrein-1
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