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kallikrein 8
Cat No.
EXWM-4113
Description
The enzyme is activated by removal of an N-terminal prepropeptide. The highest amidolytic activity is observed using Boc-Val-Pro-Arg┼7-amido-4-methylcoumarin, which is a substrate of α-thrombin. Substrates lacking basic amino acids in the P1 position are not cleaved. The enzyme degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen and is associated with diseases such as ovarian cancer and Alzheimer's disease. Belongs in peptidase family S1A.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
171715-15-4
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
KLK8; PRSS19; human kallikrein 8; hK8; mK8; ovasin; tumor-associated differentially expressed gene 14; TADG-14; NP; neuropsin
Reaction
Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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