Description
It is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM. It also inhibits closely related tyrosine kinases, Ret (180nM) and Kit (500nM). It has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
Alias
CD309, FLK1, VEGFR, VEGFR2
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Synonyms
CD309, FLK1, VEGFR, VEGFR2
Molecular Formula
C15H17ClN6O3
Chemical Name
(E)-1-(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-2-chlorophenyl)-3-ethylurea
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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