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Jervine

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Cat No.

CEI-0663

Description

Cell-permeable. Structurally similar to cyclopamine. Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine is a useful negative control.

Appearance

Yellow solid

Product Overview

A sonic hedgehog (Shh) pathway inhibitor

CAS No.

469-59-0

Molecular Weight

442.94

Purity

>97% by HPLC

Storage

-20 centigrade

Targets

SHH

Molecular Formula

C27H39NO3

Chemical Name

2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one

Solubility

DMSO (10 mM)

Shipping Conditions

Gel pack