Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

JAK3 Inhibitor IV

Cat No.
CEI-1064
Description
A (β-aminoethyl)ketone that acts as a potent and selective ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3; pIC50 = 7.1). A weak inhibitor of other tyrosine kinases (pIC50 = 5.6 for EGF-R; 4.4 for JAK1). It undergoes a retro-Michael breakdown (t1/2 = 36 min at 25centigrade, pH 7.43) to another active 2-naphthylvinyl ketone analog (JAK Inhibitor V; Cat. No. 420122) [pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1].
Abbr
JAK3 Inhibitor IV(JAK3, JAK1, EGFR)
Alias
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
CAS No.
58753-54-1
Molecular Weight
367.9
Purity
>99% by HPLC
Storage
-20 centigrade
Synonyms
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Targets
JAK-3, JAK-1, EGF-R
Molecular Formula
C23H25NO · HCl
Chemical Name
2-Naphthyl-(N-isopropyl,N-benzyl)-β-aminoethylketone, HCI, ZM 39923
Solubility
DMSO

Our Products Cannot Be Used As Medicines Directly For Personal Use.

0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product