Description
An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC50 = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 µM).
Alias
Inhibitor of Wnt Production-3
Appearance
Off-white solid
Product Overview
An inhibitor of Wnt production
Synonyms
Inhibitor of Wnt Production-3
Molecular Formula
C22H17FN4O2S3
Chemical Name
2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2- d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide
Solubility
DMSO (10 mg/ml)
Shipping Conditions
Gel pack
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