Description
A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that Itraconazole inhibits Hedgehog (Hh) signaling pathway activity (IC50 = 0.8 µM) as well as blocks the VEGFR2 glycosylation, trafficking, and signaling in endothelial cells.
Alias
Oriconazole, R51211, Sporanox
Product Overview
An antifungal agent and Hh signaling inhibitor
Synonyms
Oriconazole, R51211, Sporanox
Molecular Formula
C 35 H 38 Cl 2 N 8 O 4
Chemical Name
(2R,4S)-rel-1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
Solubility
DMSO (>20 mg/ml)
Shipping Conditions
Gel pack
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