Description
A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. Superoxide radicals can replace O2 as oxygen donor.
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
IDO (ambiguous); tryptophan pyrrolase (ambiguous); D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Reaction
(1) D-tryptophan + O2 = N-formyl-D-kynurenine; (2) L-tryptophan + O2 = N-formyl-L-kynurenine
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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