Product Overview
An IKK-3 Inhibitor. The NF-κ B/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory Iκ B proteins. NF-κ B is activated upon degradation of Iκ B following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κ B. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.