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IC-87114

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Cat No.

CEI-0141

Description

IC-87114 can inhibit PI3K-delta with IC50 of 500 nM.

CAS No.

371242-69-2

Molecular Weight

397.43

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

PI3K-delta

Molecular Formula

C22H19N7O

Chemical Name

2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one

Solubility

DMSO 0.66 mg/mL Water

In vitro

IC87114 is a selective PI3K-delta selectivity relative to the other class I PI3Ks. The IC50 of IC87114 for PI3K-delta inhibition was 0.5 uM whereas the IC50 values for PI3K-alpha, PI3K-beta, and PI3K-gamma were 100 uM, 75 uM, and 29 uM, respectively. IC87114 is 58-fold more selective for PI3K-delta relative to PI3K-gamma, and over 100-fold selective relative to PI3K-alpha and PI3K-beta.