Description
Myeloperoxidase (MPO), also known as peroxidase, is an important iron-containing lysosomal enzyme encoded in humans by the MPO gene located on chromosome 17. It is a lysosomal protein present in the aniline blue granules of neutrophils and released into the extracellular space during degranulation. MPO is more abundantly expressed in neutrophils and produces hypohalous acids with antimicrobial activity. MPO has a heme pigment that causes a green coloration of secretions in neutrophils. MPO deficiency is a genetic disorder that causes immunodeficiency in the body. Elevated levels of MPO greatly double the risk of cardiovascular death.
Source
Leukocytes in septic human sputum
Enzyme Commission Number
EC 1.11.1.7
Activity
75 - 90 units/mg of protein
Purity
Purity 95% by PAGE and gel diffusion.
Unit Definition
1 unit will decompose 1 µM of H2O2 per minute at pH 7.0 and 25°C using 4-amino-antipyrine as hydrogen donor.
Storage
Store at 5°C. Stable 1 year.
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