Description
A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase.
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Reaction
Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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