Description
A slow-releasing, water-soluble hydrogen sulfide (H₂) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
Alias
p-Methoxyphenyl)morpholino-phosphinodithioic acid
Product Overview
A slow-releasing, water-soluble hydrogen sulfide (HzS) donor
Synonyms
p-Methoxyphenyl)morpholino-phosphinodithioic acid
Targets
Proinflammatory mediators
Molecular Formula
C₁₁H₁₅NO₂PS₂ · C₄H₁₀NO
Chemical Name
p-Methoxyphenyl)morpholino-phosphinodithioic acid
Solubility
DMSO ( 20 mg/ml)
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