Description
GDA is an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human GDA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Abbr
GDA, Recombinant (Human)
Form
1 mg/ml solution 20 mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1 mM DTT.
Molecular Weight
53 kDa (477 aa, 1-454 aa + His Tag)
Purity
> 90% determined by SDS-PAGE
Unit Definition
One unit will deaminate 1.0 µmole of guanine to xanthine per minute at pH 8.0 at 25°C.
Synonyms
Guanine deaminase; CYPIN; GUANASE; NEDASIN; guanine aminase; GAH; guanine aminohydrolase; GDA
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