Description
Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (IC50> 50 µM in vitro. When administered to human primary macrophages, GSK-J4 can reduce lipopolysaccharide (LPS)-induced proinflammatory cytokine production, most notably including that of TNFα (IC50 = 9 µM).
Product Overview
Histone demethylase JMJD3/UTX inhibitor
Molecular Formula
C24H27N5O2 . HCL
Chemical Name
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2--(pyridin-2- yl)pyrimidin-4-yl)amino)propanoate, monohydrochloride
Shipping Conditions
Gel pack
Download Datasheet