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GSK-J1 sodium salt
Cat No.
CEI-0548
Description
A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.
Appearance
Liquid
Product Overview
A potent histone demethylase JMJD3/UTX inhibitor
Molecular Weight
610.63
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
KDM6B
Molecular Formula
C22H22N5O2 . Na
Chemical Name
3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate, monosodium salt
Shipping Conditions
Gel pack
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