Description
GSK690693 can inhibit akt1, akt2 and akt3 with IC50 of 2 nM, 13 nM, and 9 nM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C21H27N7O3
Chemical Name
4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-((S)-piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol
Solubility
DMSO 39 mg/mL Water
In vitro
GSK690693 is a novel ATP competitive, pan-AKT kinase inhibitor. GSK690693 can inhibit akt1, akt2 and akt3 with IC50 of 2 nM, 13 nM and 9 nM, respectively. GSK690693 block the activity of akt kinase and bind in the ATP binding pocket. GSK690693 potently inhibits intracellular AKT activity as measured by the inhibition of the phosphorylation levels of GSK3beta.
In vivo
Researchers evaluated the effect of GSK690693 on the proliferation of 112 cell lines evaluated the effect of a novel, pan-AKT kinase inhibitor, GSK690693, on the proliferation of 112 cell lines. Fifty-five percent of all cell lines tested were sensitive to AKT inhibitor (EC(50)
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