Description
Granzyme H is a member of the granzyme family of serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme H’s functions are largely unknown. The more abundant expression of Granzyme H than Granzyme B in NK cells suggests that Granzyme H may complement the pro-apoptotic function of Granzyme B in this cell type.
Source
Mouse myeloma cell line
Form
Supplied as a 0.2 μm filtered solution in HEPES, NaCl and Brij-35.
Enzyme Commission Number
EC 3.4.21.-
Activity
>5,000 pmol/min/µg
Molecular Weight
Multiple bands between 38-40 kDa, reducing conditions by SDS-PAGE
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -70 °C as supplied.
3 months, -70 °C under sterile conditions after opening.
Synonyms
Granzyme H; GZMH; Granzyme
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
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