Description
Granzyme A is a serine protease belonging to the granzyme family and is expressed exclusively by cytotoxic T cells (CTL) and NK cells. Most circulating CD56+CD8- NK cells, and approximately half of circulating CD8+ T cells, coexpress both granzymes A and B.
Form
0.22 µm filtered protein solution is in 20 mM Tris, 150 mM NaCl, pH 7.5.
Enzyme Commission Number
EC 3.4.21.78
Activity
>5,000 pmol/min/µg
Molecular Weight
55 kD in non-reducing conditions by SDS-PAGE
Purity
>90%, as determined by Coomassie stained SDS-PAGE.
Storage
Unopened vial can be stored at -70°C for six months. For maximum results, quick spin vial prior to opening. Avoid repeated freeze/thaw cycles.
Synonyms
Hanukah factor serine protease (HFSP); Cytolytic T cell-and natural killer cell-specific trypsin-like serine protease; Cytotoxic T-lymphocyte-associated serine esterase 3; CTLA3; Granzyme A; Granzyme
Endotoxin Level
Less than 1.0 EU per µg of protein as determine by the LAL method.
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