Potent and selective protein kinase C inhibitor with specificity for the alpha and beta1 isotypes. IC50=0.0084, 0.018, 0.210, 0.132 and 0.58 uM for alpha, beta1, delta, epsilon, and zeta respectively. An extremely useful tool for assessing the involvement of PKC in various signaling pathways.
Abbr
GF-109203X (PRRT2)
Alias
1. 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide 2. Bisindolylmaleimide I
Appearance
Red/orange powder
Product Overview
PKC inhibitor
CAS No.
133052-90-1
Molecular Weight
412.5
Purity
98% (TLC); NMR (Conforms)
Synonyms
1. 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide 2. Bisindolylmaleimide I
Targets
PKC
Molecular Formula
C25H24N4O2
Solubility
Soluble in dimethyl formamide or DMSO (10mg/ml, warm to 40oC)
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