Description
Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase (GGTase 1) adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif:a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.
Abbr
GGTase, Recombinant (Rat)
Activity
1 pmol of GGTase-I will transfer 5 pmol of Farnesyl to RhoA in 15 min at 37°C.
Molecular Weight
38 kDa (β subunit), 44 kDa (α subunit)
Stability
Store at -80 °C, avoid freeze/thaw cycles. Shelf Life: 12 months
Buffer
Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM TECP and 5 μM ZnCl2.
Synonyms
geranylgeranyltransferase type I; GGTase-I; GGTase; 160141-09-3; Geranylgeranyltransferase
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