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Geldanamycin
Cat No.
CEI-1022
Description
Geldanamycin is an antibiotic and a potent antitumor compound. It inhibits pp60src tyrosine kinase, and it also binds specifically to heat shock protein Hsp90 and its GP96 homologue. It is known to inhibit protein maturation.
Abbr
Geldanamycin(pp60src tyrosine kinase, HSP90AA1, HSP90B1)
Alias
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, LAP2
Appearance
Yellow crystalline solid; granular or powder.
CAS No.
30562-34-6
Molecular Weight
560.64
Purity
> 95%
Storage
Store at or below -20 centigrade. Due to reactivity, it is unstable in water and ethanol. Does not react with DMSO, but DMSO can contain moisture from the air and/or small amounts of DMSO degradation products that might react. Keep DMSO stock solutions out of contact with air.
Synonyms
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, LAP2
Targets
pp60src tyrosine kinase, Hsp90, GP96
IC50
20 nM
Molecular Formula
C29H40N2O9
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