Alias
5-Fluoracil, 5-FU, NSC19893
Storage
2 years -20centigrade Powder
Synonyms
5-Fluoracil, 5-FU, NSC19893
Targets
Thymidylate synthase
Molecular Formula
C4H3FN2O2
Chemical Name
5-Fluor-2,4-dihydroxypyrimidin
Solubility
DMSO 26 mg/mL, Water
In vitro
Adrucil is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS). Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF.
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