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Fingolimod (FTY720)
Cat No.
CEI-0330
Description
Fingolimod (FTY720) can inhibit S1P receptor with IC50 of 0.033 nM.
Alias
Gilenia
CAS No.
162359-56-0
Molecular Weight
343.9
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
Gilenia
Targets
S1P receptor
Molecular Formula
C19H33NO2.HCl
Chemical Name
2-(4-octylphenethyl)-2-aminopropane-1,3-diol hydrochloride
Solubility
DMSO 69 mg/mL Water 69 mg/mL Ethanol 69 mg/mL
In vitro
FTY720 is a S1P receptor inhibitor and it can inhibit S1P receptor with IC50 of 0.033 nM. Fingolimod represents a new generation of immunosuppressant that modulates lymphocyte trafficking by interacting with the S1P (sphingosine-1-phosphate signaling) receptor, which plays a key role in the development of immunological and neurological components of multiple sclerosis (MS).
In vivo
FTY720 induces apoptosis in prostate cancer cells by inhibition of SphK1. Research finished MTT assay and find that FTY720 induced apoptosis in PC-3 cells.
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