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Epothilone B (EPO906)
Cat No.
CEI-0288
Description
Epothilone B stabilizes microtubuli of macrophages from NMRI mice.Epothilone B can bind to microtubules with IC50 of 3.3 uM
CAS No.
152044-54-7
Molecular Weight
507.68
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Tubulin
Molecular Formula
C27H41NO6S
Chemical Name
(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
Solubility
DSMO 102 mg/mL Water
In vitro
Epothilone B stabilizes microtubuli of macrophages from NMRI mice.Epothilone B can bind to microtubules with IC50 of 3.3 uM In multidrug-resistant CCRF-CEM/VBL100 cells, IC50 values for epothilone B is 2 uM. Epothilone B can inhibit Hs578T, Hela, KB3-1, and KBV-1 with IC50 of 3 nM to 92 nM by inducing mitotic arrest.
In vivo
EpoBis highly toxic to mice and showed little therapeutic effect when compared with desoxyepothilone B.
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