Description
Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 uM for the inhibition of hERG K+ channel tail current. In preclinical studies, the compound was shown to interact selectively with the thrombopoeitin receptor, leading to activation of the JAK-STAT signaling pathway and increased proliferation and differentiation of megakaryocytes. Animal studies confirmed that administration could increase platelet counts.
Alias
SB-497115-GR, Revolade, Promacta
Storage
2 years at -20centigrade Powder
Synonyms
SB-497115-GR, Revolade, Promacta
Targets
thrombopoietin receptor
Molecular Formula
C25H22N4O4
Chemical Name
3-[(5E)-5-[[2-(3, 4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6- oxocyclohexa-1,3-dien-1-yl]benzoic acid
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