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Dovitinib Dilactic acid (TKI258 Dilactic acid)

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Cat No.

CEI-0027

Alias

CHIR-258 Dilactic acid

CAS No.

852433-84-2

Molecular Weight

572.59

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

CHIR-258 Dilactic acid

Targets

FLT3

Molecular Formula

C21H21FN6O.2C3H6O3

Solubility

In vitro

Dovitinib Dilactic acid (TKI258 Dilactic acid) is a highly potent, novel multitargeted growth factor receptor kinase inhibitor with IC50 of 1, 2, 10, 8, 27, 36 nM for FLT3, c-KIT, VEGFR1/2/3, PDGFR? and CSF-1R. Dovitinib Dilactic acid (TKI258 Dilactic acid) potently inhibits FGFR3 with an inhibitory concentration of 50% (IC50) of 5 nM in in vitro kinase assays and selectively inhibited the growth of B9 cells and human myeloma cell lines expressing wild-type (WT) or activated mutant FGFR3.