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Decitabine
Cat No.
CEI-0298
Description
Decitabine can inhibit DNA methylation.
Alias
Dacogen
CAS No.
2353-33-5
Molecular Weight
228.21
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
Dacogen
Targets
DNA methylation
Molecular Formula
C8H12N4O4
Chemical Name
4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one
Solubility
DMSO 46 mg/mL Water 10 mg/mL Ethanol 2 mg/mL
In vitro
Decitabine (5-Aza-2-deoxycytidine) is a cytosine analog with potent antileukemic activity and able to induce in vitro gene activation and cellular differentiation by a mechanism probably involving DNA hypomethylation. The incorporation of Decitabine into DNA blocks DNA methylation and can result in the activation of specific genes, such as tumor suppressor genes.
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