Description
D-Amino Acid Oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human. It is not present in plants or in bacteria which instead use D-amino acid dehydrogenase. Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide. DAAO is a candidate susceptibility gene and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia. Risperidone andsodium benzoate are inhibitors of DAAO. DAAO is used as a biocatalyst in several biotechnological applications, such as the oxidation of cephalosporin C, the deracemition of racemic D-amino acid solutions and as the biological component in several biosensors for the determination of the content in D-amino acids of biological fluids. This protein may use the morpheein model of allosteric regulation. This product with the indicated enzyme activity was briefly purified from engineered E. coli.
Applications
biotechnology; industry; drug development; medicine; pharmacology; analysis; diagnostics; synthesis
Appearance
Clear to translucent yellow solution
Enzyme Commission Number
EC 1.4.3.3
Storage
at -20 °C or lower, for at least 1 month.
Synonyms
ophio-amino-acid oxidase; L-amino acid:O 2 oxidoreductase; new yellow enzyme
Reaction
a D-amino acid + H 2 O + O 2 = a 2-oxo carboxylate + NH 3 + H 2 O 2
Notes
Since this product needs to be freshly prepared, it will take about 2 weeks after you confirm the order. Each time of the freeze-thawing may cause partial inactivation. Therefore, it should be dispensed as required and stored at -20 ° C or lower. With the preservation of the extension of time, the enzyme activity will decline to a certain extent, so the product should be used as soon as possible. This product may have turbidity or precipitation in the production and preservation process, it can be mixed after melting and will not affect the normal use. This product is limited to scientific research use, shall not be used for clinical diagnosis or treatment, shall not be used for food or medicine, shall not be stored in ordinary residential. For your safety and health, please wear an experimental suit and wear disposable gloves.
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