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Cytarabine
Cat No.
CEI-0319
Description
Cytarabine
CAS No.
147-94-4
Molecular Weight
243.22
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
DNA synthesis
Molecular Formula
C9H13N3O5
Solubility
DMSO 1 mg/mL, Water 48 mg/mL, Ethanol
In vitro
Cytarabine (AraC) is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM.
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