Description
Cystathionine gamma-lyase (CGL),or cystathionase (CSE, EC 4.4.1.1) , the enzyme participating in the synthesis of cysteine, catalyzes cystathionine deamination action, and form cysteine, alpha ketone butyric acid and NH3. In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide. Hydrogen sulfide is one of a few gases that was recently discovered to have arole in cell signaling in the body.
Applications
H2S plays an important rolein the regulation of the body's microcirculation, especially the regulation of physiological/pathological processes and related syndromes in the cardiovascular system. Because of the close relationship between CGL and H2S, the study on CGL is of great significance.
Appearance
Yellowish liquid (or lyophilized powder)
Product Overview
As a new gaseous signal molecular, H2S has the similar but different mechanisms with carbon monoxide (CO), nitric oxide (NO) in diastolic function forblood vessels, which has several function such as the proliferation of vascular smooth muscle, the dilation of coronary artery, increasing myocardial bloodflow, reducing myocardial oxygen consumption and myocardial protection. CGL is an important endogenous enzyme, which produce H2S in cardiovascular and primarily existed in the vascular smooth muscle, endothelial cells.
Enzyme Commission Number
EC 4.4.1.1
Molecular Weight
About 44kDa (SDS-PAGE detection)
Purity
>90% (SDS-PAGE test)
Storage
4°C, store at -20°C for long-term preservation.
Buffer
Phosphate buffer, pH7.4
Synonyms
Cystathionine gamma-lyase; CGL; cystathionase; CSE; EC 4.4.1.1; homoserine deaminase; homoserine dehydratase; cystine desulfhydrase; cysteine desulfhydrase; γ-cystathionase; cystathionase; homoserine deaminase-cystathionase; γ-CTL; cystalysin; cysteine lyase; L-cystathionine cysteine-lyase (deaminating); cystathionine γ-lyase
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